SMALL MOLECULE SCREEN YIELDS INHIBITORS OF PSEUDOMONAS HOMOSERINE LACTONE-INDUCED HOST RESPONSES

P. aeruginosa infections are commonly associated with cystic fibrosis, pneumonias, neutropenia and burns. The P. aeruginosa quorum sensing molecule N-(3-oxo-dodecanoyl) homoserine lactone (C12) cause multiple deleterious host responses, including repression of NF-κB transcriptional activity and apop...

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Bibliographic Details
Main Authors: Valentine, Cathleen D., Zhang, Hua, Phuan, Puay-Wah, Nguyen, Juliane, Verkman, A.S., Haggie, Peter M.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909729/
https://ncbi.nlm.nih.gov/pubmed/23910799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cmi.12176
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