P-glycoprotein induction by breast milk attenuates intestinal inflammation in experimental necrotizing enterocolitis

P-glycoprotein (Pgp), a product of the multi-drug resistance gene MDR1a, is a broad specificity efflux ATP cassette transmembrane transporter that is predominantly expressed in epithelial tissues. Because mdr1a(−/−) mice tend to develop spontaneous colitis in bacteria-dependent manner, Pgp is believ...

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Main Authors: Guner, Yigit S., Franklin, Ashanti L., Chokshi, Nikunj K., Castle, Shannon L., Pontarelli, Elizabeth, Wang, Jin, Wang, Larry, Prasadarao, Nemani V., Upperman, Jeffrey S., Grishin, Anatoly V., Ford, Henri R.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909679/
https://ncbi.nlm.nih.gov/pubmed/21788941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2011.113
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