Variants in CPA1 are strongly associated with early-onset chronic pancreatitis

Chronic pancreatitis is an inflammatory disorder of the pancreas. We analyzed CPA1 encoding carboxypeptidase A1 in subjects with non-alcoholic chronic pancreatitis and controls in a German discovery cohort and three replication cohorts. Functionally impaired variants were present in 29/944 (3.1%) Ge...

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Main Authors: Witt, Heiko, Beer, Sebastian, Rosendahl, Jonas, Chen, Jian-Min, Chandak, Giriraj Ratan, Masamune, Atsushi, Bence, Melinda, Szmola, Richárd, Oracz, Grzegorz, Macek, Milan, Bhatia, Eesh, Steigenberger, Sandra, Lasher, Denise, Bühler, Florence, Delaporte, Catherine, Tebbing, Johanna, Ludwig, Maren, Pilsak, Claudia, Saum, Karolin, Bugert, Peter, Masson, Emmanuelle, Paliwal, Sumit, Bhaskar, Seema, Sobczynska-Tomaszewska, Agnieszka, Bak, Daniel, Balascak, Ivan, Choudhuri, Gourdas, Reddy, D. Nageshwar, Rao, G. Venkat, Thomas, Varghese, Kume, Kiyoshi, Nakano, Eriko, Kakuta, Yoichi, Shimosegawa, Tooru, Durko, Lukasz, Szabó, András, Schnúr, Andrea, Hegyi, Péter, Rakonczay, Zoltán, Pfützer, Roland, Schneider, Alexander, Groneberg, David Alexander, Braun, Markus, Schmidt, Hartmut, Witt, Ulrike, Friess, Helmut, Algül, Hana, Landt, Olfert, Schuelke, Markus, Krüger, Renate, Wiedenmann, Bertram, Schmidt, Frank, Zimmer, Klaus-Peter, Kovacs, Peter, Stumvoll, Michael, Blüher, Matthias, Müller, Thomas, Janecke, Andreas, Teich, Niels, Grützmann, Robert, Schulz, Hans-Ulrich, Mössner, Joachim, Keim, Volker, Löhr, Matthias, Férec, Claude, Sahin-Tóth, Miklós
格式: Artigo
語言:Inglês
出版: 2013
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909499/
https://ncbi.nlm.nih.gov/pubmed/23955596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2730
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