Inhibition of Aldehyde Dehydrogenase Expands Hematopoietic Stem Cells with Radioprotective Capacity()

Hematopoietic stem cells (HSCs) are enriched for aldehyde dehydrogenase (ALDH) activity and ALDH is a selectable marker for human HSCs. However, the function of ALDH in HSC biology is not well understood. We sought to determine the function of ALDH in regulating HSC fate. Pharmacologic inhibition of...

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Autores principales: Muramoto, Garrett G., Russell, J. Lauren, Safi, Rachid, Salter, Alice B., Himburg, Heather A., Daher, Pamela, Meadows, Sarah K., Doan, Phuong, Storms, Robert W., Chao, Nelson J., McDonnell, Donald P., Chute, John P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909217/
https://ncbi.nlm.nih.gov/pubmed/20054864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.299
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