Negative Auto-Regulation of Myostatin Expression is Mediated by Smad3 and MicroRNA-27

Growth factors, such as myostatin (Mstn), play an important role in regulating post-natal myogenesis. In fact, loss of Mstn has been shown to result in increased post-natal muscle growth through enhanced satellite cell functionality; while elevated levels of Mstn result in dramatic skeletal muscle w...

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Main Authors: McFarlane, Craig, Vajjala, Anuradha, Arigela, Harikumar, Lokireddy, Sudarsanareddy, Ge, XiaoJia, Bonala, Sabeera, Manickam, Ravikumar, Kambadur, Ravi, Sharma, Mridula
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909192/
https://ncbi.nlm.nih.gov/pubmed/24498167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087687
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