C-Terminal Engineering of CXCL12 and CCL5 Chemokines: Functional Characterization by Electrophysiological Recordings

Chemokines are chemotactic cytokines comprised of 70–100 amino acids. The chemokines CXCL12 and CCL5 are the endogenous ligands of the CXCR4 and CCR5 G protein-coupled receptors that are also HIV co-receptors. Biochemical, structural and functional studies of receptors are ligand-consuming and the c...

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Hauptverfasser: Picciocchi, Antoine, Šiaučiūnaiteė-Gaubard, Lina, Petit-Hartlein, Isabelle, Sadir, Rabia, Revilloud, Jean, Caro, Lydia, Vivaudou, Michel, Fieschi, Franck, Moreau, Christophe, Vivès, Corinne
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909184/
https://ncbi.nlm.nih.gov/pubmed/24498095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087394
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