Dual Blockade of the Homeostatic Chemokine CXCL12 and the Proinflammatory Chemokine CCL2 Has Additive Protective Effects on Diabetic Kidney Disease

Monocyte/ chemoattractant protein-1/chemokine ligand (CCL) 2 and stromal cell–derived factor-1/CXCL12 both contribute to glomerulosclerosis in mice with type 2 diabetes mellitus, through different mechanisms. CCL2 mediates macrophage-related inflammation, whereas CXCL12 contributes to podocyte loss....

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Bibliographische Detailangaben
Hauptverfasser: Darisipudi, Murthy N., Kulkarni, Onkar P., Sayyed, Sufyan G., Ryu, Mi, Migliorini, Adriana, Sagrinati, Costanza, Parente, Eliana, Vater, Axel, Eulberg, Dirk, Klussmann, Sven, Romagnani, Paola, Anders, Hans-Joachim
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2011
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Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123871/
https://ncbi.nlm.nih.gov/pubmed/21703397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.03.004
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