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Use of Preclinical Dog Studies and Absorption Modeling to Facilitate Late Stage Formulation Bridging for a BCS II Drug Candidate

Formulation changes are common during drug development either due to clinical or manufacturing considerations. These changes especially at later stages of drug development oftentimes raise questions on the potential impact of a new formulation on bioavailability. In this work, the preclinical assess...

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Bibliografiske detaljer
Hovedforfatter: Kesisoglou, Filippos
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909157/
https://ncbi.nlm.nih.gov/pubmed/24022346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-013-0030-6
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