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Enantioselective Synthesis of Cyclobutanes via Sequential Rh-catalyzed Bicyclobutanation/Cu-catalyzed Homoconjugate Addition

Enantiomerically enriched cyclobutanes are constructed by a three-component process in which t-butyl (E)-2-diazo-5-arylpent-4-enoates are treated with Rh(2)(S-NTTL)(4) to provide enantiomerically enriched bicyclobutanes, which can subsequently engage in homoconjugate addition/enolate trapping sequen...

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Autores principales: Panish, Robert, Chintala, Srinivasa R., Boruta, David T., Fang, Yinzhi, Taylor, Michael T., Fox, Joseph M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908885/
https://ncbi.nlm.nih.gov/pubmed/23758288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja403811t
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