An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective.

Overactivation of calcium-activated neutral protease (calpain) has been implicated in the pathophysiology of several degenerative conditions, including stroke, myocardial ischemia, neuromuscular degeneration, and cataract formation. Alpha-mercaptoacrylate derivatives (exemplified by PD150606), with...

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Detalhes bibliográficos
Main Authors: Wang, K K, Nath, R, Posner, A, Raser, K J, Buroker-Kilgore, M, Hajimohammadreza, I, Probert A, W, Marcoux, F W, Ye, Q, Takano, E, Hatanaka, M, Maki, M, Caner, H, Collins, J L, Fergus, A, Lee, K S, Lunney, E A, Hays, S J, Yuen, P
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC39087/
https://ncbi.nlm.nih.gov/pubmed/8692879
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