A specific inhibitor of calcium/calmodulin-dependent protein kinase-II provides neuroprotection against NMDA- and hypoxia/hypoglycemia-induced cell death

Calcium/calmodulin-dependent protein kinase-II (CamK-II) is a major neuronal protein which plays a significant role in the cellular process of long-term potentiation (LTP), and vesicular release of neurotransmitters. Here, we show that KN-62, 1-[N,O-bis(5- isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4...

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Publicat a:J Neurosci
Autors principals: Hajimohammadreza, I, Probert, AW, Coughenour, LL, Borosky, SA, Marcoux, FW, Boxer, PA, Wang, KK
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 1995
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6578204/
https://ncbi.nlm.nih.gov/pubmed/7538570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.15-05-04093.1995
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