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Engineered antibody therapies to counteract mutant huntingtin and related toxic intracellular proteins
The engineered antibody approach to Huntington's disease (HD) therapeutics is based on the premise that significantly lowering the levels of the primary misfolded mutant protein will reduce abnormal protein interactions and direct toxic effects of the misfolded huntingtin (HTT). This will in tu...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3908675/ https://ncbi.nlm.nih.gov/pubmed/22120646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pneurobio.2011.11.004 |
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