Thioredoxin-mediated Denitrosylation Regulates Cytokine-induced Nuclear Factor κB (NF-κB) Activation

S-nitrosylation of nuclear factor κB (NF-κB) on the p65 subunit of the p50/p65 heterodimer inhibits NF-κB DNA binding activity. We have recently shown that p65 is constitutively S-nitrosylated in the lung and that LPS-induced injury elicits a decrease in SNO-p65 levels concomitant with NF-κB activat...

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Bibliographische Detailangaben
Hauptverfasser: Kelleher, Zachary T., Sha, Yonggang, Foster, Matthew W., Foster, W. Michael, Forrester, Michael T., Marshall, Harvey E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908436/
https://ncbi.nlm.nih.gov/pubmed/24338024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.503938
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