Down-modulation of SEL1L, an Unfolded Protein Response and Endoplasmic Reticulum-associated Degradation Protein, Sensitizes Glioma Stem Cells to the Cytotoxic Effect of Valproic Acid

Valproic acid (VPA), an histone deacetylase inhibitor, is emerging as a promising therapeutic agent for the treatments of gliomas by virtue of its ability to reactivate the expression of epigenetically silenced genes. VPA induces the unfolded protein response (UPR), an adaptive pathway displaying a...

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Bibliografiska uppgifter
Huvudupphovsmän: Cattaneo, Monica, Baronchelli, Simona, Schiffer, Davide, Mellai, Marta, Caldera, Valentina, Saccani, Gloria Jotti, Dalpra, Leda, Daga, Antonio, Orlandi, Rosaria, DeBlasio, Pasquale, Biunno, Ida
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2014
Ämnen:
Neurobiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908415/
https://ncbi.nlm.nih.gov/pubmed/24311781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.527754
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