Down-modulation of SEL1L, an Unfolded Protein Response and Endoplasmic Reticulum-associated Degradation Protein, Sensitizes Glioma Stem Cells to the Cytotoxic Effect of Valproic Acid

Valproic acid (VPA), an histone deacetylase inhibitor, is emerging as a promising therapeutic agent for the treatments of gliomas by virtue of its ability to reactivate the expression of epigenetically silenced genes. VPA induces the unfolded protein response (UPR), an adaptive pathway displaying a...

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Bibliografiske detaljer
Main Authors: Cattaneo, Monica, Baronchelli, Simona, Schiffer, Davide, Mellai, Marta, Caldera, Valentina, Saccani, Gloria Jotti, Dalpra, Leda, Daga, Antonio, Orlandi, Rosaria, DeBlasio, Pasquale, Biunno, Ida
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Neurobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908415/
https://ncbi.nlm.nih.gov/pubmed/24311781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.527754
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