Proteasome Inhibition Increases Recruitment of IκB Kinase β (IKKβ), S536P-p65, and Transcription Factor EGR1 to Interleukin-8 (IL-8) Promoter, Resulting in Increased IL-8 Production in Ovarian Cancer Cells

Proinflammatory and pro-angiogenic chemokine interleukin-8 (IL-8, CXCL8) contributes to ovarian cancer progression through its induction of tumor cell proliferation, survival, angiogenesis, and metastasis. Proteasome inhibition by bortezomib, which has been used as a frontline therapy in multiple my...

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Main Authors: Singha, Bipradeb, Gatla, Himavanth Reddy, Manna, Subrata, Chang, Tzu-Pei, Sanacora, Shannon, Poltoratsky, Vladimir, Vancura, Ales, Vancurova, Ivana
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908402/
https://ncbi.nlm.nih.gov/pubmed/24337575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.502641
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