Binding of a possible transition state analogue to the active site of carboxypeptidase A.
The mode of binding of the competitive inhibitor 2-benzyl-3-formylpropanoic acid to the active site of carboxypeptidase A has been studied by x-ray diffraction methods to a resolution of 1.7 A. The actual species bound to the enzyme was determined to be the gem-diol resulting from covalent hydration...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1985
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC390783/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3863130/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.20.6840 |
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