Ebselen induces reactive oxygen species (ROS)-mediated cytotoxicity in Saccharomyces cerevisiae with inhibition of glutamate dehydrogenase being a target()

Ebselen is a synthetic, lipid-soluble seleno-organic compound. The high electrophilicity of ebselen enables it to react with multiple cysteine residues of various proteins. Despite extensive research on ebselen, its target molecules and mechanism of action remains less understood. We performed bioch...

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Huvudupphovsmän: Azad, Gajendra Kumar, Singh, Vikash, Mandal, Papita, Singh, Prabhat, Golla, Upendarrao, Baranwal, Shivani, Chauhan, Sakshi, Tomar, Raghuvir S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907691/
https://ncbi.nlm.nih.gov/pubmed/24490132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2014.01.002
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