Preclinical Evaluation of Engineered Oncolytic Herpes Simplex Virus for the Treatment of Pediatric Solid Tumors

Recently, investigators showed that mice with syngeneic murine gliomas that were treated with a neuroattenuated oncolytic herpes simplex virus-1 (oHSV), M002, had a significant increase in survival. M002 has deletions in both copies of the γ(1)34.5 gene, enabling replication in tumor cells but precl...

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Main Authors: Megison, Michael L., Gillory, Lauren A., Stewart, Jerry E., Nabers, Hugh C., Mroczek-Musulman, Elizabeth, Waters, Alicia M., Coleman, Jennifer M., Kelly, Virginia, Markert, James M., Gillespie, G. Yancey, Friedman, Gregory K., Beierle, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907427/
https://ncbi.nlm.nih.gov/pubmed/24497984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086843
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