Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan

Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven uniqueness in humans and its prominent role in geriatrics and gerontology. We use large samples of longitudinally followed populations from the Framingham Heart Study (FHS) original and offspring coho...

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Hauptverfasser: Kulminski, Alexander M., Arbeev, Konstantin G., Culminskaya, Irina, Arbeeva, Liubov, Ukraintseva, Svetlana V., Stallard, Eric, Christensen, Kaare, Schupf, Nicole, Province, Michael A., Yashin, Anatoli I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907310/
https://ncbi.nlm.nih.gov/pubmed/24497847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004141
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