In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis

BACKGROUND: The HIV-1 accessory protein, Nef, is decisive for progression to AIDS. In vitro characterization of the protein has described many Nef activities of unknown in vivo significance including CD4 downregulation and a number of activities that depend on Nef interacting with host SH3 domain pr...

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Bibliographic Details
Main Authors: Watkins, Richard L, Zou, Wei, Denton, Paul W, Krisko, John F, Foster, John L, Garcia, J Victor
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907037/
https://ncbi.nlm.nih.gov/pubmed/24172637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-125
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