Cell-selective knockout and 3D confocal image analysis reveals separate roles for astrocyte-and endothelial-derived CCL2 in neuroinflammation

BACKGROUND: Expression of chemokine CCL2 in the normal central nervous system (CNS) is nearly undetectable, but is significantly upregulated and drives neuroinflammation during experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis which is considered a contributing f...

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Detalhes bibliográficos
Main Authors: Paul, Debayon, Ge, Shujun, Lemire, Yen, Jellison, Evan R, Serwanski, David R, Ruddle, Nancy H, Pachter, Joel S
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906899/
https://ncbi.nlm.nih.gov/pubmed/24444311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-11-10
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