Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis

BACKGROUND: The greatest genetic risk factor for late-onset Alzheimer's disease (AD) is the ϵ4 allele of Apolipoprotein E (ApoE). ApoE regulates secretion of the potent neuroprotective signaling lipid Sphingosine 1-phosphate (S1P). S1P is derived by phosphorylation of sphingosine, catalysed by...

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Detalhes bibliográficos
Main Authors: Couttas, Timothy A, Kain, Nupur, Daniels, Benjamin, Lim, Xin Ying, Shepherd, Claire, Kril, Jillian, Pickford, Russell, Li, Hongyun, Garner, Brett, Don, Anthony S
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906863/
https://ncbi.nlm.nih.gov/pubmed/24456642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-2-9
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