Phase I study of the combination of sorafenib and temsirolimus in patients with metastatic melanoma

PURPOSE: This phase I clinical trial was conducted to determine the safety, efficacy, and molecular effects of sorafenib with temsirolimus in patients with advanced melanoma. PATIENTS AND METHODS: Patients with stage IV or unresectable or recurrent stage III melanoma and ECOG performance status of 0...

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Hlavní autoři: Davies, Michael A., Fox, Patricia S., Papadopoulos, Nicholas E., Bedikian, Agop Y., Hwu, Wen-Jen, Lazar, Alexander J. F., Prieto, Victor G., Culotta, Kirk S., Madden, Timothy L., Xu, Quanyun, Huang, Sha, Deng, Wanleng, Ng, Chaan, Gupta, Sanjay, Liu, Wenbin, Dancey, Janet E., Wright, John J., Bassett, Roland L., Hwu, Patrick, Kim, Kevin B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906678/
https://ncbi.nlm.nih.gov/pubmed/22223528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2436
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