Innate Immune Activation in the Pathogenesis of a Murine Model of Globoid Cell Leukodystrophy

Globoid cell leukodystrophy is a lysosomal storage disease characterized by the loss of galactocerebrosidase. Galactocerebrosidase loss leads to the accumulation of psychosine and subsequent oligodendrocyte cell death, demyelination, macrophage recruitment, and astroglial activation and proliferatio...

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Detalhes bibliográficos
Main Authors: Snook, Eric R., Fisher-Perkins, Jeanne M., Sansing, Hope A., Lee, Kim M., Alvarez, Xavier, MacLean, Andrew G., Peterson, Karin E., Lackner, Andrew A., Bunnell, Bruce A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2014
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906490/
https://ncbi.nlm.nih.gov/pubmed/24316110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.10.011
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