microRNA-34a promotes DNA damage and mitotic catastrophe

Efficient and error-free DNA repair is critical for safeguarding genome integrity, yet it is also linked to radio- and chemoresistance of malignant tumors. miR-34a, a potent tumor suppressor, influences a large set of p53-regulated genes and contributes to p53-mediated apoptosis. However, the effect...

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Autores principales: Kofman, Alexander V, Kim, Jungeun, Park, So Yeon, Dupart, Evan, Letson, Christopher, Bao, Yongde, Ding, Kai, Chen, Quan, Schiff, David, Larner, James, Abounader, Roger
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906336/
https://ncbi.nlm.nih.gov/pubmed/24091633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.26459
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