Multidimensional Single-Cell Analysis of BCR Signaling Reveals Proximal Activation Defect As a Hallmark of Chronic Lymphocytic Leukemia B Cells

PURPOSE: Chronic Lymphocytic Leukemia (CLL) is defined by a perturbed B-cell receptor-mediated signaling machinery. We aimed to model differential signaling behavior between B cells from CLL and healthy individuals to pinpoint modes of dysregulation. EXPERIMENTAL DESIGN: We developed an experimental...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Palomba, M. Lia, Piersanti, Kelly, Ziegler, Carly G. K., Decker, Hugo, Cotari, Jesse W., Bantilan, Kurt, Rijo, Ivelise, Gardner, Jeff R., Heaney, Mark, Bemis, Debra, Balderas, Robert, Malek, Sami N., Seymour, Erlene, Zelenetz, Andrew D., van den Brink, Marcel R. M., Altan-Bonnet, Grégoire
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2014
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906024/
https://ncbi.nlm.nih.gov/pubmed/24489640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079987
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