Discovery of a Small Molecule Agonist of Phosphatidylinositol 3-Kinase p110α That Reactivates Latent HIV-1

Combination antiretroviral therapy (cART) can effectively suppress HIV-1 replication, but the latent viral reservoir in resting memory CD4(+) T cells is impervious to cART and represents a major barrier to curing HIV-1 infection. Reactivation of latent HIV-1 represents a possible strategy for elimin...

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Detalhes bibliográficos
Main Authors: Doyon, Geneviève, Sobolewski, Michele D., Huber, Kelly, McMahon, Deborah, Mellors, John W., Sluis-Cremer, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906007/
https://ncbi.nlm.nih.gov/pubmed/24489654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084964
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