The mycobacterial antibiotic resistance determinant WhiB7 acts as a transcriptional activator by binding the primary sigma factor SigA (RpoV)

Tuberculosis therapeutic options are limited by the high intrinsic antibiotic resistance of Mycobacterium tuberculosis. The putative transcriptional regulator WhiB7 is crucial for the activation of systems that provide resistance to diverse antibiotic classes. Here, we used in vitro run-off, two-hyb...

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Bibliographic Details
Main Authors: Burian, Ján, Yim, Grace, Hsing, Michael, Axerio-Cilies, Peter, Cherkasov, Artem, Spiegelman, George B., Thompson, Charles J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Gene Regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905903/
https://ncbi.nlm.nih.gov/pubmed/23990327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt751
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