Catalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, (31)P-NMR spectroscopy and reaction path modelling

Enzymatic synthesis and hydrolysis of nucleoside phosphate compounds play a key role in various biological pathways, like signal transduction, DNA synthesis and metabolism. Although these processes have been studied extensively, numerous key issues regarding the chemical pathway and atomic movements...

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Detalhes bibliográficos
Main Authors: Barabás, Orsolya, Németh, Veronika, Bodor, Andrea, Perczel, András, Rosta, Edina, Kele, Zoltán, Zagyva, Imre, Szabadka, Zoltán, Grolmusz, Vince I., Wilmanns, Matthias, Vértessy, Beáta G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905902/
https://ncbi.nlm.nih.gov/pubmed/23982515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt756
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