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Selective alkylation of carcinogenic 9-anthryloxirane at the N-3 position of adenine in DNA.

Carcinogenic 9-anthryloxirane binds covalently to calf thymus DNA and poly(dA-dT). Application of the technique for DNA sequence determination shows that acid cleavage of the modified DNA frees approximately half of the anthryl groups from the DNA. HPLC analysis indicates that an adenine adduct and...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Yang, N C, Chang, C W
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1985
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC390545/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3860860/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.16.5250
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