Hemin inhibits internalization of transferrin by reticulocytes and promotes phosphorylation of the membrane transferrin receptor.

Addition of hemin to reticulocytes inhibits incorporation of iron from transferrin [Ponka, P. & Neuwirt, J. (1969) Blood 33, 609-707]. Heme also regulates protein synthesis in immature erythroid cells through its effects on phosphorylation of the initiation factor eIF-2. We have therefore examined i...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Cox, T M, O'Donnell, M W, Aisen, P, London, I M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1985
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC390521/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2991909/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.15.5170
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