Hemin inhibits internalization of transferrin by reticulocytes and promotes phosphorylation of the membrane transferrin receptor.

Addition of hemin to reticulocytes inhibits incorporation of iron from transferrin [Ponka, P. & Neuwirt, J. (1969) Blood 33, 609-707]. Heme also regulates protein synthesis in immature erythroid cells through its effects on phosphorylation of the initiation factor eIF-2. We have therefore examin...

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Bibliografiske detaljer
Main Authors: Cox, T M, O'Donnell, M W, Aisen, P, London, I M
Format: Artigo
Sprog:Inglês
Udgivet: 1985
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC390521/
https://ncbi.nlm.nih.gov/pubmed/2991909
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