High expression of leptin receptor leads to temozolomide resistance with exhibiting stem/progenitor cell features in gliobalastoma

Glioblastoma is a highly aggressive malignant disease with notable resistance to chemotherapy. In this study, we found that leptin receptor (ObR)-positive glioblastoma cells were resistant to temozolomide (TMZ), and TMZ-resistant cells exhibited high expression of ObR. ObR can serve as a marker to e...

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Detalhes bibliográficos
Main Authors: Han, Guosheng, Wang, Laixing, Zhao, Wenyuan, Yue, Zhijian, Zhao, Rui, Li, Yanan, Zhou, Xiaoping, Hu, Xiaowu, Liu, Jianmin
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905075/
https://ncbi.nlm.nih.gov/pubmed/24131927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.26809
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