Hypoxia Increases Gefitinib-Resistant Lung Cancer Stem Cells through the Activation of Insulin-Like Growth Factor 1 Receptor

Accumulating evidence indicates that a small population of cancer stem cells (CSCs) is involved in intrinsic resistance to cancer treatment. The hypoxic microenvironment is an important stem cell niche that promotes the persistence of CSCs in tumors. Our aim here was to elucidate the role of hypoxia...

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Detalhes bibliográficos
Main Authors: Murakami, Akiko, Takahashi, Fumiyuki, Nurwidya, Fariz, Kobayashi, Isao, Minakata, Kunihiko, Hashimoto, Muneaki, Nara, Takeshi, Kato, Motoyasu, Tajima, Ken, Shimada, Naoko, Iwakami, Shin-ichiro, Moriyama, Mariko, Moriyama, Hiroyuki, Koizumi, Fumiaki, Takahashi, Kazuhisa
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904884/
https://ncbi.nlm.nih.gov/pubmed/24489728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086459
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