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Structural basis for action by diverse antidepressants on biogenic amine transporters

The biogenic amine transporters (BATs) regulate endogenous neurotransmitter concentrations and are targets for a broad range of therapeutic agents that include selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs) and tricyclic antidepressants (TCAs)(1...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wang, Hui, Goehring, April, Wang, Kevin H, Penmatsa, Aravind, Ressler, Ryan, Gouaux, Eric
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904662/
https://ncbi.nlm.nih.gov/pubmed/24121440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12648
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