Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production

Chronic hyperglycemia impairs insulin action, resulting in glucotoxicity, which can be ameliorated in animal models by inducing glucosuria with renal glucose transport inhibitors. Here, we examined whether reduction of plasma glucose with a sodium-glucose cotransporter 2 (SGLT2) inhibitor could impr...

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Bibliografiske detaljer
Main Authors: Merovci, Aurora, Solis-Herrera, Carolina, Daniele, Giuseppe, Eldor, Roy, Fiorentino, Teresa Vanessa, Tripathy, Devjit, Xiong, Juan, Perez, Zandra, Norton, Luke, Abdul-Ghani, Muhammad A., DeFronzo, Ralph A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904617/
https://ncbi.nlm.nih.gov/pubmed/24463448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70704
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