Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production

Chronic hyperglycemia impairs insulin action, resulting in glucotoxicity, which can be ameliorated in animal models by inducing glucosuria with renal glucose transport inhibitors. Here, we examined whether reduction of plasma glucose with a sodium-glucose cotransporter 2 (SGLT2) inhibitor could impr...

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Главные авторы: Merovci, Aurora, Solis-Herrera, Carolina, Daniele, Giuseppe, Eldor, Roy, Fiorentino, Teresa Vanessa, Tripathy, Devjit, Xiong, Juan, Perez, Zandra, Norton, Luke, Abdul-Ghani, Muhammad A., DeFronzo, Ralph A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2014
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904617/
https://ncbi.nlm.nih.gov/pubmed/24463448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70704
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