Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses Kras(G12D)-driven lung tumorigenesis

Cullin-RING ligases (CRLs) are a family of E3 ubiquitin ligase complexes that rely on either RING-box 1 (RBX1) or sensitive to apoptosis gene (SAG), also known as RBX2, for activity. RBX1 and SAG are both overexpressed in human lung cancer; however, their contribution to patient survival and lung tu...

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Главные авторы: Li, Hua, Tan, Mingjia, Jia, Lijun, Wei, Dongping, Zhao, Yongchao, Chen, Guoan, Xu, Jie, Zhao, Lili, Thomas, Dafydd, Beer, David G., Sun, Yi
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2014
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904615/
https://ncbi.nlm.nih.gov/pubmed/24430184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70297
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