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SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation

SAG/RBX/ROC protein is an essential RING component of SCF E3 ubiquitin ligase. The role of SAG during embryogenesis remains unknown. We report here a critical role for SAG in controlling vascular and neural development by modulating RAS activity via promoting degradation of neurofibromatosis type 1...

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Detalhes bibliográficos
Main Authors: Tan, Mingjia, Zhao, Yongchao, Kim, Sun-Jung, Liu, Margaret, Jia, Lijun, Saunders, Thomas L., Zhu, Yuan, Sun, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241850/
https://ncbi.nlm.nih.gov/pubmed/22118770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2011.09.014
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