Evidence for Activation of the Unfolded Protein Response in Collagen IV Nephropathies

Thin-basement-membrane nephropathy (TBMN) and Alport syndrome (AS) are progressive collagen IV nephropathies caused by mutations in COL4A3/A4/A5 genes. These nephropathies invariably present with microscopic hematuria and frequently progress to proteinuria and CKD or ESRD during long-term follow-up....

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Main Authors: Pieri, Myrtani, Stefanou, Charalambos, Zaravinos, Apostolos, Erguler, Kamil, Stylianou, Kostas, Lapathitis, George, Karaiskos, Christos, Savva, Isavella, Paraskeva, Revekka, Dweep, Harsh, Sticht, Carsten, Anastasiadou, Natassa, Zouvani, Ioanna, Goumenos, Demetris, Felekkis, Kyriakos, Saleem, Moin, Voskarides, Konstantinos, Gretz, Norbert, Deltas, Constantinos
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2014
Teme:
Basic Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904556/
https://ncbi.nlm.nih.gov/pubmed/24262798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012121217
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