Structure–activity relationships of the N-terminus of calcitonin gene-related peptide: key roles of alanine-5 and threonine-6 in receptor activation

Background and Purpose: The N-terminus of calcitonin gene-related peptide (CGRP) is important for receptor activation, especially the disulphide-bonded ring (residues 1–7). However, the roles of individual amino acids within this region have not been examined and so the molecular determinants of ago...

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Detalhes bibliográficos
Main Authors: Hay, Debbie L, Harris, Paul WR, Kowalczyk, Renata, Brimble, Margaret A, Rathbone, Dan L, Barwell, James, Conner, Alex C, Poyner, David R
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & sons 2014
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904261/
https://ncbi.nlm.nih.gov/pubmed/24125506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12464
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