Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology

BACKGROUND AND PURPOSE: Receptor activity-modifying proteins (RAMPs) define the pharmacology of the calcitonin receptor-like receptor (CLR). The interactions of the different RAMPs with this class B GPCR yield high-affinity calcitonin gene-related peptide (CGRP) or adrenomedullin (AM) receptors. How...

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Hauptverfasser: Watkins, H A, Walker, C S, Ly, K N, Bailey, R J, Barwell, J, Poyner, D R, Hay, D L
Format: Artigo
Sprache:Inglês
Veröffentlicht: British Journal of Pharmacology 2014
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969088/
https://ncbi.nlm.nih.gov/pubmed/24199627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12508
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