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Characterization of a new V gene replacement in the absence of activation-induced cytidine deaminase and its contribution to human B-cell receptor diversity

In B cells, B-cell receptor (BCR) immunoglobulin revision is a common route for modifying unwanted antibody specificities via a mechanism called VH replacement. This in vivo process, mostly affecting heavy-chain rearrangement, involves the replacement of all or part of a previously rearranged IGHV g...

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Détails bibliographiques
Auteurs principaux: Ouled-Haddou, Hakim, Ghamlouch, Hussein, Regnier, Aline, Trudel, Stephanie, Herent, Didier, Lefranc, Marie-Paule, Marolleau, Jean Pierre, Gubler, Brigitte
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904247/
https://ncbi.nlm.nih.gov/pubmed/24134819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12192
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