LSN2424100: a novel, potent orexin-2 receptor antagonist with selectivity over orexin-1 receptors and activity in an animal model predictive of antidepressant-like efficacy

We describe a novel, potent and selective orexin-2 (OX2)/hypocretin-2 receptor antagonist with in vivo activity in an animal model predictive of antidepressant-like efficacy. N-biphenyl-2-yl-4-fluoro-N-(1H-imidazol-2-ylmethyl) benzenesulfonamide HCl (LSN2424100) binds with high affinity to recombina...

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Bibliographische Detailangaben
Hauptverfasser: Fitch, Thomas E., Benvenga, Mark J., Jesudason, Cynthia D., Zink, Charity, Vandergriff, Amy B., Menezes, Michelle M., Schober, Douglas A., Rorick-Kehn, Linda M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2014
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904085/
https://ncbi.nlm.nih.gov/pubmed/24478625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2014.00005
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