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2′-O-methyl-modified phosphorothioate antisense oligonucleotides have reduced non-specific effects in vitro
Antisense oligodeoxynucleotides (ODNs) have biological activity in treating various forms of cancer. The antisense effects of two types of 20mer ODNs, phosphorothioate-modified ODNs (S-ODNs) and S-ODNs with 12 2′-O-methyl groups (Me-S-ODNs), targeted to sites 109 and 277 of bcl-2 mRNA, were compared...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2004
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC390367/ https://ncbi.nlm.nih.gov/pubmed/15064360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh516 |
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