Oct4 Mediates Tumor Initiating Properties in Oral Squamous Cell Carcinomas through the Regulation of Epithelial-Mesenchymal Transition

BACKGROUND: Overexpression of Oct4, an important transcription factor of embryonic stem cells (ESC), has been reported in several cancers. The aim of this study was to determine the emerging role of Oct4 in oral squamous cell carcinoma (OSCC) both in vitro and in vivo. METHODOLOGY/PRINCIPAL FINDING:...

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Bibliographic Details
Main Authors: Tsai, Lo-Lin, Hu, Fang-Wei, Lee, Shiuan-Shinn, Yu, Chuan-Hang, Yu, Cheng-Chia, Chang, Yu-Chao
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903644/
https://ncbi.nlm.nih.gov/pubmed/24475251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087207
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