Phospholipase C-β1 and β4 Contribute to Non-Genetic Cell-to-Cell Variability in Histamine-Induced Calcium Signals in HeLa Cells

A uniform extracellular stimulus triggers cell-specific patterns of Ca(2+) signals, even in genetically identical cell populations. However, the underlying mechanism that generates the cell-to-cell variability remains unknown. We monitored cytosolic inositol 1,4,5-trisphosphate (IP(3)) concentration...

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Hlavní autoři: Ishida, Sachiko, Matsu-ura, Toru, Fukami, Kiyoko, Michikawa, Takayuki, Mikoshiba, Katsuhiko
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903530/
https://ncbi.nlm.nih.gov/pubmed/24475116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086410
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