Linker-Extended Native Cyanovirin-N Facilitates PEGylation and Potently Inhibits HIV-1 by Targeting the Glycan Ligand

Cyanovirin-N (CVN) potently inhibits human immunodeficiency virus type 1 (HIV-1) infection, but both cytotoxicity and immunogenicity have hindered the translation of this protein into a viable therapeutic. A molecular docking analysis suggested that up to 12 residues were involved in the interaction...

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Detalhes bibliográficos
Main Authors: Chen, Jia, Huang, Dane, Chen, Wei, Guo, Chaowan, Wei, Bo, Wu, Chongchao, Peng, Zhou, Fan, Jun, Hou, Zhibo, Fang, Yongsheng, Wang, Yifei, Kitazato, Kaio, Yu, Guoying, Zou, Chunbin, Qian, Chuiwen, Xiong, Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903522/
https://ncbi.nlm.nih.gov/pubmed/24475123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086455
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