Proteinase Activated Receptor 1 Mediated Fibrosis in a Mouse Model of Liver Injury: A Role for Bone Marrow Derived Macrophages

Liver fibrosis results from the co-ordinated actions of myofibroblasts and macrophages, a proportion of which are of bone marrow origin. The functional effect of such bone marrow-derived cells on liver fibrosis is unclear. We examine whether changing bone marrow genotype can down-regulate the liver&...

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Main Authors: Kallis, Yiannis N., Scotton, Christopher J., MacKinnon, Alison C., Goldin, Robert D., Wright, Nicholas A., Iredale, John P., Chambers, Rachel C., Forbes, Stuart J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2014
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903514/
https://ncbi.nlm.nih.gov/pubmed/24475094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086241
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