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Aberrant antibody affinity selection in SHIP-deficient B cells

The strength of the Ag receptor signal influences development and negative selection of B cells, and it might also affect B-cell survival and selection in the GC. Here, we have used mice with B-cell-specific deletion of the 5′-inositol phosphatase SHIP as a model to study affinity selection in cells...

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Détails bibliographiques
Auteurs principaux: Leung, Wai-Hang, Tarasenko, Tatiana, Biesova, Zuzana, Kole, Hemanta, Walsh, Elizabeth R., Bolland, Silvia
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903325/
https://ncbi.nlm.nih.gov/pubmed/23135975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201242809
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